Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mmp13  matrix metallopeptidase 13   (Synonyms: Clg, collagenase-1, Collagenase-3, interstitial collagenase, Mmp1, MMP-13)
Results	Reference
1	J:108824 Casey LM, Lan Y, Cho ES, Maltby KM, Gridley T, Jiang R, Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn. 2006 Apr 10;235(7):1830-1844
1	J:208766 Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Ruegg MA, Hall MN, Ma L, Long F, WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014 Jan;10(1):e1004145
1	J:90362 Colnot C, Lu C, Hu D, Helms JA, Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Dev Biol. 2004 May 1;269(1):55-69
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:214092 Firulli BA, Fuchs RK, Vincentz JW, Clouthier DE, Firulli AB, Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61
1*	J:26819 Gack S, Vallon R, Schmidt J, Grigoriadis A, Tuckermann J, Schenkel J, Weiher H, Wagner EF, Angel P, Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ. 1995 Jun;6(6):759-67
1	J:192183 Gkantidis N, Blumer S, Katsaros C, Graf D, Chiquet M, Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo. PLoS One. 2012;7(10):e47762
1	J:150187 Guo X, Mak KK, Taketo MM, Yang Y, The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009;4(6):e6067
1*	J:233142 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
1*	J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
1*	J:161213 Jin JZ, Tan M, Warner DR, Darling DS, Higashi Y, Gridley T, Ding J, Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn. 2010 Jul;239(7):2110-7
1*	J:222305 Jin JZ, Warner DR, Ding J, Regional divergence of palate medial edge epithelium along the anterior to posterior axis. Int J Dev Biol. 2014;58(9):713-7
1	J:162579 Kashiwagi A, Schipani E, Fein MJ, Greer PA, Shimada M, Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation. Mol Cell Biol. 2010 Jun;30(11):2799-810
1	J:182744 Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ, Cartilage-specific RBPjkappa-dependent and -independent Notch signals regulate cartilage and bone development. Development. 2012 Mar;139(6):1198-212
1	J:264609 Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y, Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203
1	J:151888 Mead TJ, Yutzey KE, Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14420-5
1*	J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
1	J:316655 Oh SK, Shin JO, Baek JI, Lee J, Bae JW, Ankamerddy H, Kim MJ, Huh TL, Ryoo ZY, Kim UK, Bok J, Lee KY, Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB J. 2015 Nov;29(11):4473-84
1	J:135374 Patra D, Xing X, Davies S, Bryan J, Franz C, Hunziker EB, Sandell LJ, Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol. 2007 Nov 19;179(4):687-700
1	J:244304 Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J, p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828
1	J:150009 Richardson RJ, Dixon J, Jiang R, Dixon MJ, Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence. Hum Mol Genet. 2009 Jul 15;18(14):2632-42
1	J:247121 Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ, HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci. 2016 Jun 01;129(11):2145-55
1	J:330577 Shin M, Mori S, Mizoguchi T, Arai A, Kajiya H, Okamoto F, Bartlett JD, Matsushita M, Udagawa N, Okabe K, Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis. Bone. 2022 Oct 7;166:116579
1	J:163656 Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafe L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR, Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21;362(3):206-16
1	J:88817 Smits P, Dy P, Mitra S, Lefebvre V, Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58
1*	J:273625 Takahashi M, Fujikawa K, Angammana R, Shibata S, An in situ hybridization study of MMP-2, -9, -13, -14, TIMP-1, and -2 mRNA in fetal mouse mandibular condylar cartilage as compared with limb bud cartilage. Gene Expr Patterns. 2019 Feb 27;32:1-11
1	J:117333 Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F, Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007 Jan;12(1):113-27